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 <div v:shape="_x0000_s18434" class=T style='text-align:center;mso-char-wrap:
 1;mso-kinsoku-overflow:1;position:absolute;top:13.66%;left:8.5%;width:83.12%;
 height:7.5%'><span lang=EN-US style='font-size:82%;color:#3333CC;mso-color-index:
 5;mso-fareast-language:ZH-TW'>(4) Rates per user per day </span></div>
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 <div style='mso-char-wrap:1;mso-kinsoku-overflow:1'><span style='position:
 absolute;top:27.0%;left:11.5%;width:90.62%;height:5.0%'><span
 style='font-size:75%;font-weight:normal'><span style='mso-special-format:bullet;
 color:#006600;position:absolute;left:-4.13%;top:-.3em;font-family:Wingdings;
 font-size:150%'>§</span></span><span lang=EN-US style='font-size:75%;
 mso-fareast-language:ZH-TW'>to determine whether the DDD is close to the
 average </span></span><span style='position:absolute;top:32.33%;left:11.5%;
 width:92.25%;height:5.0%'><span lang=EN-US style='font-size:75%;mso-fareast-language:
 ZH-TW'>daily maintenance dose for the drug’s main indication </span></span><span
 style='position:absolute;top:37.66%;left:11.5%;width:79.37%;height:5.0%'><span
 lang=EN-US style='font-size:75%;mso-fareast-language:ZH-TW'>(as determined by
 WHO). &#13;</span></span></div>
 <div style='mso-char-wrap:1;mso-kinsoku-overflow:1'><span style='position:
 absolute;top:44.0%;left:11.5%;width:79.37%;height:5.0%'><span
 style='font-size:75%;font-weight:normal'><span style='mso-special-format:bullet;
 color:#006600;position:absolute;left:-4.72%;top:-.3em;font-family:Wingdings;
 font-size:150%'>§</span></span><span lang=EN-US style='font-size:75%;
 mso-fareast-language:ZH-TW'># of DDDs per day per user <br>
  </span></span><span style='position:absolute;top:49.33%;left:11.5%;
 width:90.25%;height:5.0%'><span lang=EN-US style='font-size:75%;mso-fareast-language:
 ZH-TW'>= 750,000 DDDs per year / 365 days per year / 10,000 </span></span><span
 style='position:absolute;top:54.66%;left:11.5%;width:79.37%;height:5.0%'><span
 lang=EN-US style='font-size:75%;mso-fareast-language:ZH-TW'>users <br>
  </span></span><span style='position:absolute;top:60.0%;left:11.5%;width:79.37%;
 height:5.0%'><span lang=EN-US style='font-size:75%;mso-fareast-language:ZH-TW'>=
 0.21 DDDs per user per day&#13;</span></span></div>
 <div style='mso-char-wrap:1;mso-kinsoku-overflow:1'><span style='position:
 absolute;top:66.33%;left:11.5%;width:92.0%;height:5.0%'><span
 style='font-size:75%;font-weight:normal'><span style='mso-special-format:bullet;
 color:#006600;position:absolute;left:-4.07%;top:-.3em;font-family:Wingdings;
 font-size:150%'>§</span></span><span lang=EN-US style='font-size:75%;
 mso-fareast-language:ZH-TW'>We expect this measure to be close to 1 for drugs
 used </span></span><span style='position:absolute;top:71.66%;left:11.5%;
 width:92.12%;height:5.0%'><span lang=EN-US style='font-size:75%;mso-fareast-language:
 ZH-TW'>for chronic diseases (i.e., for drugs for which the DDD </span></span><span
 style='position:absolute;top:77.0%;left:11.5%;width:94.37%;height:5.0%'><span
 lang=EN-US style='font-size:75%;mso-fareast-language:ZH-TW'>is likely to be
 prescribed for every user for every day of </span></span><span
 style='position:absolute;top:82.33%;left:11.5%;width:79.37%;height:5.0%'><span
 lang=EN-US style='font-size:75%;mso-fareast-language:ZH-TW'>the year). </span></span></div>
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