Investigation on the Domestic Measles Outbreak in Nantou, 2014

Hsin-Yi Wei1*, Du-Ling Lin2, Chia-Su Wu2, Su-Ling Pan2, Wen-Yueh Cheng3, Hao-Yuan Cheng1, Wan-Chin Chen1

2015 Vol.31 NO.9

Correspondence Author: Hsin-Yi Wei

  • 1.Office of Preventive Medicine, Taiwan Centers of Disease Control, Ministry of Health and Welfare, Taiwan
  • 2.Central Regional Center, Centers for Disease Control, Ministry of Health and Welfare, Taiwan
  • 3.Center for Research, Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan


On 16 October 2014, one hospital in Nantou reported ameasles case. Since 24 October, there were several measles cases reported, and confirmedto be a domestic measles outbreak. The index patient had not traveled abroadand the infection source was unknown. The second patient was the elder sister ofindex patient; the third and fourth patients were cousins of index patient.These secondary cases all had contact with index patient during his transmissibleperiod. Besides, the 18 month-old nephew of the third patient who just receivedMeasles-Mumps-Rubella (MMR) vaccination three months before experienced feverwithout rash. The lab result was positive for measles and confirmed to bevaccine-modified measles infection. Measles virus is highly contagious butvaccine preventable. However, primary vaccine failure occurs 5% to 10% ofchildren at 1 year of age. Also, the immunity might wane off after time inyoung people who have not experienced natural infection. We recommend routineMMR vaccination and additional shots if working with exposure risk or travelingto endemic area.

Keywords:Measles;Vaccine-modified measles infection;Immunity waning