Reinfection of Invasive Streptococcus pneumoniae － Analysis of Notifiable Diseases Database in Taiwan

Sheng-Yi Chuang, Che-Chieh Yen, Chi-Ching Huang

2010 Vol.26 NO.2

Correspondence Author： Sheng-Yi Chuang

Abstract：

Abstract

This study describes the epidemiology of invasive Streptococcus pneumoniae based on Notifiable Diseases Database between October 15, 2007 and June 30, 2009. There were 1,366 confirmed cases, with 67 % male and 9.7 % mortality. Persons under five years of age and over 64 years old together represented majority of cases. According to 2008 data, the annual incidence was 3.5 per 100,000 populations, and mortality was 0.48 per 100,000 population. Among 27.6% of patients have underlying diseases, the identified top seven serotypes were 14, 23F, 3, 6B, 19F, 19A, 23A, and the disease was more prevalent in spring and winter.
We identified seven patients, 6 were male, with reinfection from the notifiable diseases database. These patients aged 2 to 87 years old, and had one reinfection. They all had underlying diseases which made them more vulnerable to reinfection. The time between the two infections in these patients ranged from 38 to 390 days. Two patients were infected twice with bacteria of the same serotype (23, and 6B). The seven patients all survived. This is the first epidemiological analysis of invasive Streptococcal pneumoniae in Taiwan, which may provide useful information for clinical practice and public health authorities.