The Antigenic and Phylogenetic Analysis of Surface Protein Genes of Influenza A Viruses in Taiwan, 2004-2007

Shu-Chun Chiu

2009 Vol.25 NO.5

Correspondence Author： Shu-Chun Chiu

Abstract：

The genetic mutation of influenza viruses (flu viruses) can produce different effects on viral antigenicity. Moreover, genetic changes in key amino acid of influenza viruses may play a major role in global influenza pandemic. Earlier research had found that different genetic changes on haemagglutinin (HA) and neuraminidase (NA) can affect deeply to the antigenicity of influenza viruses. The information constantly collected through monitoring on genetic and antigenic mutations of influenza viruses is important and crucial, to both the control of epidemic status, and the annual selection of influenza vaccine strain To understand the gene mutations of influenza viruses, evaluate the possibility of influenza pandemic, and explore the correlation between gene sequence evolution and antigenicity changes of the viruses in Taiwan, we sequenced the surface protein genes from local influenza virus isolates and analyzed with bioinformatic techniques. Furthermore, sequence analysis of internal matrix protein gene to find out the drug resistance pattern to amantadine, an antiviral drug for influenza A infections, during the surveillance period in Taiwan, and the data can be used as a reference for treatment and medication.
Keywords: influenza A viruses, antigenicity, sequence analysis, Taiwan