Study on HLA Types and SCE Frequency in Familial and Sporadic Nasopharyngeal Carcinoma


1989 Vol.5 NO.5

Correspondence Author:


Correspondence Author:

Nasopharyngeal carcinoma has a higher prevalence rate in Chinese than in other ethnic groups This difference has attracted the attention of many epidemiologists, and many risk factors such as EB virus, smoking, Cantonese salted fish, which containing nitrosamine, occupational exposures, genetic factors, and history of nasal cavity diseases, etc have been suggested No study, however, has yet established the temporality of causal relation between any of these factors and the nasopharyngeal carcinoma Even the most mentioned EB virus, many facts still remain unexplained For instance, the male-female ratio of nasopharyngeal carcinoma is 2-3:1, the infection of EB virus in male and female is about the same Simons et al1 , therefore, proposed a hypothesis on Human Leukocyte Antigen (HLA) and nasopharyngeal carcinoma However, many studies in different areas with different ethnic groups have so far produced inconsistent findings