| 梅毒分類 | 對象 | 首選治療藥物 | 替代治療藥物 |
| 早期梅毒 (一期、二期、早期潛伏性) |
成人 | Benzathine penicillin G 2.4 million units (IM, single dose) |
Doxycycline 100mg (PO, bid, 14 days) |
| Ceftriaxone 1g (IV, qd, 10 days) |
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| 孕婦 | Benzathine penicillin G 2.4 million units (IM, single dose) |
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| 晚期梅毒 (晚期潛伏性梅毒、 腦脊髓液檢查正常的三期梅毒、 梅毒腫、心血管性梅毒) |
成人 | Benzathine penicillin G 2.4 million units (IM, 3 doses each at 1-week intervals) |
Doxycycline 100mg (PO, bid, 28 days) |
| 孕婦 | Benzathine penicillin G 2.4 million units (IM, 3 doses each at 1-week intervals) |
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| 神經性梅毒 | 成人 | aqueous crystalline penicillin G 18-24 million units (IV, every 4 hours 3-4 million units or continuous infusion, 10-14 days) |
Ceftriaxone 1-2g (IM/IV, qd, 10-14 days) |
| procaine penicillin G 2.4 million units (IM, qd) +probenecid 500mg (PO, qid) 10-14 days |